skip to main content

Sneddon Syndrome — SCE Rheumatology MCQ

Instant feedback + full explanation. One question, done properly.

HardSLE & Antiphospholipid SyndromeSneddon SyndromeSCE Rheumatology

A 45-year-old woman with SLE develops livedo reticularis cognitive dysfunction and multiple cerebral white matter lesions on MRI. She has strongly positive antiphospholipid antibodies but does not meet criteria for TIA or stroke. What clinical syndrome should be considered?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: B — Sneddon syndrome (livedo reticularis with cerebrovascular disease)

The best answer is “Sneddon syndrome (livedo reticularis with cerebrovascular disease)”. Sneddon syndrome (livedo reticularis with cerebrovascular disease) is supported by the cited UK or directly applicable specialist authority and best matches the tested threshold, complication or monitoring principle. The remaining choices—“Migraine with aura, after safety review, after safety review”, “Normal pressure hydrocephalus, after specialist assessment”, “Vasculitis, with clinical reassessment, with clinical reassessment”, “Multiple sclerosis, after safety review, within a rheumatology pathway”—are credible in related rheumatology presentations, but each addresses a different diagnosis, investigation, treatment sequence or complication and does not fit the decisive findings in this stem.

Reference: EULAR recommendations for systemic lupus erythematosus: https://ard.bmj.com/content/83/1/15