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DAS28 Components — SCE Rheumatology MCQ

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EasyRheumatoid ArthritisDAS28 ComponentsSCE Rheumatology

A 45-year-old woman with rheumatoid arthritis is having her four-variable DAS28-ESR calculated. Which set of variables is used?

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Correct answer: D28-tender joint count, 28-swollen joint count, ESR and patient global health VAS

The four-variable DAS28-ESR combines the 28-tender joint count, 28-swollen joint count, ESR and the patient’s global health assessment on a 0–100 visual analogue scale. Therefore, D is correct. An analogous DAS28-CRP incorporates CRP rather than ESR, but patient pain alone and physician global assessment are not the required global component, excluding A and D. The HAQ-DI measures functional disability and is not part of DAS28, excluding C. Rheumatoid factor titre and duration of morning stiffness are also not included, excluding E. The 28-joint counts cover the shoulders, elbows, wrists, MCP joints, PIP joints and knees; ankles and feet are not included, which is a recognised limitation.

Reference: EULAR Outcome Measures Library. Disease Activity Scores with 28-joint counts (DAS28), instrument description. https://oml.eular.org/oml_search_results_details.cfm?action=All+information&id=157