Behcet VTE Management — SCE Rheumatology MCQ
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Correct answer: E — Systemic anti-inflammatory or immunosuppressive treatment, without routine adjunctive anticoagulation
Explanation lettering: D = shown as A · E = shown as B · B = shown as C · A = shown as D · C = shown as E
Behçets-associated venous thrombosis is primarily an inflammatory vascular manifestation, so treatment should target active vessel-wall inflammation. Current BAD–BSR living guidance supports systemic anti-inflammatory or immunosuppressive treatment for Behçets-associated DVT and does not recommend routine addition of anticoagulation. The potential benefit of anticoagulation is uncertain, whereas bleeding can be catastrophic when arterial disease, particularly pulmonary arterial aneurysm, coexists. Anticoagulation alone (B or E) does not treat the underlying inflammatory process. Observation alone (A) is inadequate for symptomatic DVT. Thrombolysis (D) is not routine treatment for uncomplicated lower-limb DVT in Behçets and does not replace immunosuppression.
Reference: Murphy R, Moots RJ, Brogan P, et al. British Association of Dermatologists and British Society for Rheumatology living guideline for managing people with Behçets 2025. Rheumatology (Oxford). 2026;65(2):keaf521. https://pubmed.ncbi.nlm.nih.gov/41042599/