Methotrexate Safety — SCE Rheumatology MCQ
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Correct answer: E — 2.5 mg tablets only to reduce dosing error risk
BSR 2025 csDMARD guidelines specifically state that only 2.5 mg Methotrexate tablets should be prescribed for adult patients with systemic autoimmune rheumatic diseases. The 10 mg tablet has been implicated in serious and fatal dosing errors when patients inadvertently take 10 mg tablets in place of 2.5 mg tablets resulting in four-fold overdose. This safety recommendation aims to prevent a well-documented and recurring cause of Methotrexate toxicity. Prescribers should ensure prescriptions specify 2.5 mg tablets.
Reference: BSR 2025 - Guideline for prescription and monitoring of conventional synthetic DMARDs