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Takayasu Arteritis — SCE Rheumatology MCQ

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HardVasculitisTakayasu ArteritisSCE Rheumatology

A patient with systemic sclerosis continues to develop new ischaemic digital ulcers despite vasodilator optimisation. Bosentan is selected to reduce new-ulcer formation. Which oral schedule is authorised?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — Start 62.5 mg twice daily for 4 weeks, then increase to 125 mg twice daily

Explanation lettering: B = shown as A · C = shown as B · E = shown as C · A = shown as E

A is correct. For systemic-sclerosis digital-ulcer disease, bosentan begins at 62.5 mg twice daily for four weeks and is then increased to 125 mg twice daily. Treatment is specialist initiated and monitored, including hepatic safety and pregnancy prevention. Once-daily consolidation and starting at the maintenance dose do not match the studied or authorised regimen.

Reference: Bosentan 62.5 mg film-coated tablets SmPC: https://www.medicines.org.uk/emc/product/820/smpc