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JAK Inhibitor Screening — SCE Rheumatology MCQ

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HardRheumatology PharmacologyJAK Inhibitor ScreeningSCE Rheumatology

A patient with rheumatoid arthritis is being considered for a JAK inhibitor. Which baseline safety bundle is required before treatment?

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Correct answer: EFull blood count, liver and renal profile, lipids, hepatitis and TB screening

Baseline JAK-inhibitor assessment includes haematology, hepatic and renal function, lipid status, viral hepatitis and latent-tuberculosis screening, together with infection, vaccination, malignancy, cardiovascular and thromboembolic risk review.

Reference: UK Rinvoq summary of product characteristics (Current UK SmPC, accessed 30 July 2026): https://www.medicines.org.uk/emc/product/13935/smpc; MHRA: JAK inhibitors — measures to reduce cardiovascular, malignancy, VTE, infection and mortality risks (Published April 2023): https://www.gov.uk/drug-safety-update/janus-kinase-jak-inhibitors-new-measures-to-reduce-risks-of-major-cardiovascular-events-malignancy-venous-thromboembolism-serious-infections-and-increased-mortality