Takayasu Arteritis — SCE Rheumatology MCQ
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Correct answer: D — Any previous stroke contraindicates romosozumab in the UK SmPC
Explanation lettering: D = shown as A · C = shown as B · A = shown as C · B = shown as D
B is correct. The UK SmPC contraindicates romosozumab in patients with a history of myocardial infarction or stroke; it does not restrict that contraindication to events in the previous year. Aspirin co-treatment and dose reduction do not remove the labelled cardiovascular risk. This differs from looser wording sometimes encountered in secondary summaries.
Reference: Evenity 105 mg pre-filled pen SmPC: https://www.medicines.org.uk/emc/product/10956/smpc