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SLE — SCE Rheumatology MCQ

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EasySLE & Antiphospholipid SyndromeSLESCE Rheumatology

A 27-year-old woman with newly diagnosed SLE has positive anti-dsDNA and low complement. She has arthritis and malar rash but no renal involvement. According to EULAR 2023, which medication should ALL SLE patients receive regardless of disease severity?

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Correct answer: E — Hydroxychloroquine

EULAR 2023 recommends Hydroxychloroquine for ALL patients with SLE at a target dose of 5 mg/kg real body weight/day, regardless of disease severity. HCQ reduces flare frequency, damage accrual, and thrombotic risk. It also improves survival. Retinal monitoring is required (baseline assessment, then annual screening from year 5 per RCOphth). HCQ should be continued during pregnancy. Methotrexate and Azathioprine are used for more active disease. Biologics are reserved for refractory cases.

Reference: EULAR 2023 - Recommendations for the management of SLE