skip to main content

SLE — SCE Rheumatology MCQ

Instant feedback + full explanation. One question, done properly.

ModerateSLE & Antiphospholipid SyndromeSLESCE Rheumatology

A 35-year-old woman with SLE and class III focal proliferative lupus nephritis (ISN/RPS) has completed 6 months of Mycophenolate induction with good response. Proteinuria has fallen from 3.2 g/day to 0.4 g/day. What is the recommended maintenance therapy?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — Continue Mycophenolate as maintenance

For lupus nephritis maintenance, EULAR 2023 recommends Mycophenolate mofetil or Azathioprine. If the patient responded well to Mycophenolate induction, continuing Mycophenolate as maintenance is preferred over switching agents. The recommended duration of maintenance is at least 3 years before considering tapering. Cyclophosphamide is an induction agent only and not appropriate for maintenance due to cumulative toxicity. Methotrexate and Leflunomide are not standard maintenance agents for lupus nephritis.

Reference: EULAR 2023 - Recommendations for management of SLE