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Dermatomyositis — SCE Rheumatology MCQ

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HardMyositisDermatomyositisSCE Rheumatology

A 50-year-old woman with dermatomyositis has anti-NXP2 (anti-MJ) antibody positivity. What clinical phenotype is most associated with this antibody?

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Correct answer: DSevere calcinosis and malignancy risk in adults

The best answer is “Severe calcinosis and malignancy risk in adults”. Severe calcinosis and malignancy risk in adults is supported by the cited UK or directly applicable specialist authority and best matches the tested threshold, complication or monitoring principle. The remaining choices—“Skin-predominant disease principally, with clinical reassessment”, “Anti-synthetase syndrome overlap, within a rheumatology pathway”, “Limited skin and mild muscle involvement”, “Necrotising myopathy, after specialist assessment”—are credible in related rheumatology presentations, but each addresses a different diagnosis, investigation, treatment sequence or complication and does not fit the decisive findings in this stem.

Reference: BSR guideline on idiopathic inflammatory myopathy: https://academic.oup.com/rheumatology/article/61/5/1760/6555980