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Antiphospholipid Syndrome — SCE Rheumatology MCQ

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HardSLE & Antiphospholipid SyndromeAntiphospholipid SyndromeSCE Rheumatology

A pregnant patient with obstetric APS develops pre-eclampsia and placental insufficiency despite low-dose aspirin and prophylactic LMWH. Which principle is most appropriate for a future pregnancy?

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Correct answer: D — Pre-pregnancy multidisciplinary review of refractory obstetric APS

Failure of standard obstetric APS prophylaxis requires specialist pre-pregnancy review to confirm adherence, antibody profile and placental diagnosis and to individualise options such as hydroxychloroquine or adjusted heparin. DOACs are not used during pregnancy, and routine prolonged high-dose steroids cause harm.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/musculoskeletal-conditions