SLE — SCE Rheumatology MCQ

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ModerateSLE & Antiphospholipid SyndromeSLESCE Rheumatology

A 35-year-old woman with SLE asks about the recommended target dose of Hydroxychloroquine according to EULAR 2023 guidelines. She weighs 60 kg. What daily dose should be targeted?

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Correct answer: A — 5 mg/kg/day

EULAR 2023 recommends Hydroxychloroquine for all SLE patients at a target dose of 5 mg/kg real body weight per day, considering individual risk of flares and retinal toxicity. For a 60 kg patient this would be 300 mg/day. The previous maximum of 6.5 mg/kg/day is no longer the target due to retinal toxicity risk. In moderate-severe cases the initial dose may exceed 5 mg/kg (up to 400 mg/day) then adjusted later.

Reference: EULAR 2023 - Recommendations for the management of systemic lupus erythematosus