Rheumatoid Arthritis — SCE Rheumatology MCQ

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HardRheumatoid ArthritisRheumatoid ArthritisSCE Rheumatology

A 40-year-old woman with RA on Methotrexate is being started on Adalimumab. Which screening investigation is most important before initiation?

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Correct answer: C — Interferon-gamma release assay for tuberculosis

The best answer is “Interferon-gamma release assay for tuberculosis”. Interferon-gamma release assay for tuberculosis is supported by the cited UK or directly applicable specialist authority and best matches the tested threshold, complication or monitoring principle. The remaining choices—“Echocardiogram, within a rheumatology pathway”, “Colonoscopy, after safety review”, “CT chest abdomen pelvis”, “Bone densitometry, within a rheumatology pathway”—are credible in related rheumatology presentations, but each addresses a different diagnosis, investigation, treatment sequence or complication and does not fit the decisive findings in this stem.

Reference: NICE NG100 rheumatoid arthritis in adults: https://www.nice.org.uk/guidance/ng100/chapter/Recommendations