A 40-year-old man from the Mekong Delta, Vietnam, presents with right upper quadrant pain, fever, and eosinophilia. He regularly eats raw freshwater f...

Question

A 40-year-old man from the Mekong Delta, Vietnam, presents with right upper quadrant pain, fever, and eosinophilia. He regularly eats raw freshwater fish. Stool examination reveals small operculated eggs. He is treated with praziquantel 25 mg/kg TDS for 2 days. What is the mechanism of action of praziquantel?

Accepted Answer

Increased calcium permeability of the parasite tegument, causing spastic paralysis and tegumental disruption

Answer

Inhibition of parasite tubulin polymerisation

Answer

Inhibition of parasite mitochondrial electron transport

Answer

Blockade of parasite neuromuscular junction

Answer

Inhibition of folate synthesis in the parasite

uk-dtmh MCQ (SBA): Praziquantel Mechanism of Action