A 29-year-old woman has chronic diarrhoea, weight loss and iron-deficiency anaemia. Tissue transglutaminase IgA antibodies are strongly positive. What...

Question

A 29-year-old woman has chronic diarrhoea, weight loss and iron-deficiency anaemia. Tissue transglutaminase IgA antibodies are strongly positive. What is the most appropriate next step in confirming the diagnosis?

Accepted Answer

Duodenal biopsy while continuing a gluten-containing diet

Answer

Start a gluten-free diet immediately and recheck antibodies in 6 months

Answer

Colonoscopy and random colonic biopsies only

Answer

Empirical steroids for presumed inflammatory bowel disease

Answer

Hydrogen breath test for lactose intolerance

uk-plab-1 MCQ (SBA): Coeliac disease

A 29-year-old woman has chronic diarrhoea, weight loss and iron-deficiency anaemia. Tissue transglutaminase IgA antibodies are strongly positive. What is the most appropriate next step in confirming the diagnosis?