A 67-year-old obese man with type 2 diabetes and established coronary artery disease has HbA₁c of 74 mmol/mol despite lifestyle measures. According to...

Question

A 67-year-old obese man with type 2 diabetes and established coronary artery disease has HbA₁c of 74 mmol/mol despite lifestyle measures. According to NICE NG28 and its 2025 update, what is the most appropriate first-line pharmacological strategy?

Accepted Answer

Start Metformin and consider early addition of an SGLT2 inhibitor because of cardiovascular disease.

Answer

Start Metformin alone.

Answer

Start a sodium–glucose co-transporter 2 (SGLT2) inhibitor alone.

Answer

Start a sulfonylurea such as Gliclazide alone.

Answer

Start insulin therapy immediately.

uk-plab-1 MCQ (SBA): Type 2 diabetes mellitus

A 67-year-old obese man with type 2 diabetes and established coronary artery disease has HbA₁c of 74 mmol/mol despite lifestyle measures. According to NICE NG28 and its 2025 update, what is the most appropriate first-line pharmacological strategy?