A 28-year-old man from a high TB prevalence country has a positive interferon gamma release assay (IGRA) but a normal chest X-ray and no symptoms. Wha...

Question

A 28-year-old man from a high TB prevalence country has a positive interferon gamma release assay (IGRA) but a normal chest X-ray and no symptoms. What is the most appropriate management?

Accepted Answer

Start treatment for latent TB infection with an isoniazid-containing regimen after exclusion of active disease

Answer

Reassure; no treatment is required

Answer

Start full four-drug TB treatment immediately

Answer

Repeat IGRA in 3 months and treat only if still positive

Answer

Vaccinate with BCG

au-amc MCQ (SBA): Latent tuberculosis infection

A 28-year-old man from a high TB prevalence country has a positive interferon gamma release assay (IGRA) but a normal chest X-ray and no symptoms. What is the most appropriate management?