A 70-year-old man with type 2 diabetes and chronic kidney disease presents with oedema, weight gain and rising creatinine after starting high-dose ibu...

Question

A 70-year-old man with type 2 diabetes and chronic kidney disease presents with oedema, weight gain and rising creatinine after starting high-dose ibuprofen for back pain. Which mechanism best explains the acute kidney injury?

Accepted Answer

Reduced renal perfusion due to NSAID-induced afferent arteriolar vasoconstriction

Answer

Immune complex deposition in glomeruli

Answer

Obstructive uropathy

Answer

Direct tubular toxicity of insulin

Answer

Prerenal azotaemia due to ACE inhibitor alone

au-amc MCQ (SBA): NSAID-associated acute kidney injury

A 70-year-old man with type 2 diabetes and chronic kidney disease presents with oedema, weight gain and rising creatinine after starting high-dose ibuprofen for back pain. Which mechanism best explains the acute kidney injury?