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COPD Exacerbation — SCE Respiratory MCQ

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Hard"Respiratory Medicine"COPD ExacerbationSCE Respiratory

A woman with asthma and recurrent nasal polyposis develops bronchospasm and rhinorrhoea 45 minutes after ibuprofen. She tolerates paracetamol. Which diagnostic and management principle is most appropriate?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: BAvoid strong COX-1 inhibitors and obtain specialist phenotype assessment

Asthma, nasal polyposis and a rapid respiratory reaction to a non-selective NSAID suggest NSAID-exacerbated respiratory disease, a pharmacological COX-1 intolerance rather than a drug-specific IgE allergy. Strong COX-1 inhibitors should be avoided; specialist assessment can address cross-reactivity, safe alternatives and whether supervised challenge or desensitisation is justified.

Reference: NHS Specialist Pharmacy Service advice on NSAID use in asthma (Current NHS medicines advice, accessed 30 July 2026): https://www.sps.nhs.uk/articles/using-nsaids-in-asthma/; EAACI position paper on NSAID-exacerbated respiratory disease (Published 2019): https://pmc.ncbi.nlm.nih.gov/articles/PMC7729240/