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COPD — SCE Respiratory MCQ

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ModerateRespiratory MedicineCOPDSCE Respiratory

A 70-year-old with COPD had >= 2 moderate exacerbations last year; eosinophils 350/µL. Appropriate initial inhaled therapy?

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Correct answer: A — LABA/LAMA/ICS triple therapy

For frequent exacerbators (Group E) with eosinophils >= 300/µL, initial triple therapy (LABA/LAMA/ICS) can be considered to reduce exacerbations. SABA alone, single long-acting bronchodilators, or LABA/LAMA without ICS may be insufficient given eosinophilia and exacerbation history.

Reference: GOLD Pocket Guide (2025): Global Strategy for COPD