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COPD Exacerbation Prevention — SCE Respiratory MCQ

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HardRespiratory MedicineCOPD Exacerbation PreventionSCE Respiratory

A patient with multisystem sarcoidosis develops polyuria, hypernatraemia and absent posterior-pituitary bright spot on MRI. What complication is most likely?

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Correct answer: C — Hypothalamic-pituitary sarcoidosis causing central diabetes insipidus

Neurosarcoidosis can infiltrate the hypothalamic-pituitary axis and cause central diabetes insipidus, often with other anterior-pituitary deficits. Treatment requires coordinated endocrine, neurological and sarcoidosis assessment rather than assuming hypercalcaemia is the sole mechanism.

Reference: https://www.brit-thoracic.org.uk/quality-improvement/guidelines/