vibegron at a glance
Medicine class
Selective beta-3 adrenergic receptor agonist
Licensed use
Symptoms of overactive bladder syndrome in adults
Food
May be taken with or without food
Important risk
Difficulty emptying the bladder, particularly with bladder outlet obstruction or an antimuscarinic
What is vibegron used for?
Vibegron is licensed for symptomatic treatment of overactive bladder syndrome in adults.
Sudden compelling urges to urinate
Unusually frequent urination
Urge urinary incontinence, where urgency is followed by leakage
How does vibegron work?
Vibegron selectively activates beta-3 adrenergic receptors in the bladder’s detrusor muscle. This relaxes the muscle during bladder filling, increasing storage capacity and helping reduce urgency, frequency and urge-related leakage.
vibegron preparations and strengths
Tablet
Route: Oral
Strengths: 75 mg
How to take vibegron
Follow the instructions provided by the prescriber and pharmacy label.
Swallow the tablet with a glass of water.
It may be taken with or without food.
If necessary, crush the tablet and mix it with soft food. Take the mixture immediately and then drink water.
vibegron side effects
Common or expected effects
- Urinary tract infection
- Headache
- Diarrhoea
- Feeling sick
- Constipation
- Increased urine remaining in the bladder after urination
Get urgent medical advice
- Inability to empty the bladder or marked difficulty passing urine needs prompt medical assessment.
vibegron in pregnancy
Human pregnancy information is absent or very limited, and animal studies identified reproductive toxicity. Vibegron is not recommended during pregnancy or when planning pregnancy. Contact the prescriber if pregnancy occurs so treatment can be reviewed.
vibegron while breastfeeding
It is unknown whether vibegron enters human milk, and a risk to a breastfed infant cannot be excluded. It should not be used while breastfeeding; discuss alternatives with the prescriber.
vibegron interactions
Tell the prescriber or pharmacist about all medicines being used, particularly the following.
Digoxin
Vibegron can increase digoxin exposure, so blood concentrations should be monitored and treatment adjusted where necessary.
Dabigatran etexilate, apixaban or rivaroxaban
These are sensitive P-glycoprotein substrates with a narrow safety margin; the potential interaction should be considered clinically.
Antimuscarinic bladder medicines
Combined treatment may increase the risk of urinary retention, especially where bladder outlet obstruction is present.
Common questions about vibegron
Answers are fully visible for fast scanning and source review.
What symptoms does vibegron treat?
It treats adult overactive bladder symptoms: urgency, increased urinary frequency and urge urinary incontinence.
Is vibegron an anticholinergic medicine?
No. It is a beta-3 adrenergic receptor agonist that relaxes the bladder during filling.
Can vibegron be taken with food?
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.