Sebetralstat at a glance
Medicine class
Competitive, reversible plasma kallikrein inhibitor
Licensed role
Treatment of HAE attacks in adults and adolescents aged 12 years and older
Route
Film-coated tablet taken by mouth
Food
May be taken with or without food
What is Sebetralstat used for?
Licensed use:
Treatment of hereditary angioedema attacks in adults and adolescents aged 12 years and older.
It treats acute attacks and is not licensed as regular preventive treatment.
How does Sebetralstat work?
Sebetralstat reversibly blocks plasma kallikrein. This reduces formation of bradykinin, which increases blood-vessel leakage and causes HAE swelling.
Sebetralstat preparations and strengths
Tablet
Route: Oral
Strengths: 300 mg
How to take Sebetralstat
Use sebetralstat according to the HAE attack plan agreed with the prescriber.
Swallow the film-coated tablet whole, using water if needed.
It may be taken with or without food.
Check with the prescriber or pharmacist if other medicines have changed because interactions can alter sebetralstat exposure.
Sebetralstat side effects
Common or expected effects
- Headache
- Indigestion
Sebetralstat in pregnancy
There are no human pregnancy data. As a precaution, the product information advises avoiding sebetralstat during pregnancy and in people who could become pregnant without effective, medically appropriate contraception. Specialist review is important.
Sebetralstat while breastfeeding
It is unknown whether sebetralstat passes into human milk, and risk to the infant cannot be excluded. The prescriber and patient should decide whether to pause breastfeeding or avoid sebetralstat after weighing the benefits to parent and child.
Sebetralstat interactions
Review all prescribed, non-prescribed and herbal products before sebetralstat is supplied or used.
Strong CYP3A4 inhibitors, including itraconazole, ketoconazole, ritonavir or clarithromycin
May substantially increase sebetralstat exposure, requiring review of the attack plan.
Strong or moderate CYP3A4 inducers, including phenytoin, carbamazepine, phenobarbital, rifampicin or efavirenz
May markedly reduce sebetralstat exposure and potentially reduce its effect.
Metformin
Sebetralstat may increase metformin exposure through renal transporter inhibition. Consider renal function and lactate monitoring in people at higher risk of lactic acidosis.
Common questions about Sebetralstat
Answers are fully visible for fast scanning and source review.
What is Sebetralstat used for?
It is licensed to treat HAE attacks in adults and adolescents aged 12 years and older.
Does Sebetralstat prevent hereditary angioedema attacks?
Its licence covers treatment of an attack, not regular long-term prevention.
Does Sebetralstat cure hereditary angioedema?
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.