Nicotinamide contributes to the coenzymes NAD and NADP, which support cellular oxidation-reduction reactions. Its benefit in inflammatory acne is thought to relate mainly to local anti-inflammatory activity; it is not an antibiotic.

Freederm Treatment 4% w/w Gel — Current selected SmPC PubMed

nicotinamide preparations and strengths

Gel

Route: Cutaneous

Strengths: 4% w/w

Freederm Treatment 4% w/w Gel — Current selected SmPC

nicotinamide side effects

Common or expected effects

Dry skin
Itching
Redness
Burning sensation
Local irritation

Freederm Treatment 4% w/w Gel — Current selected SmPC

nicotinamide in pregnancy

The product information states that there are no specific pregnancy restrictions or known potential risks, but advises caution, particularly during the first trimester. Discuss use with a pharmacist, doctor or midwife if pregnant or planning pregnancy.

Freederm Treatment 4% w/w Gel — Current selected SmPC

nicotinamide while breastfeeding

The patient leaflet gives no specific restriction on topical use during breastfeeding, although nicotinamide can enter breast milk after systemic exposure. Ask a healthcare professional for advice, particularly before applying it near the breast.

Freederm Treatment 4% w/w Gel — Current selected SmPC

nicotinamide interactions

No interactions with other medicines are known for the selected topical product.

Other medicines

No medicine interactions are identified in the current product information.

Freederm Treatment 4% w/w Gel — Current selected SmPC

Common questions about nicotinamide

Answers are fully visible for fast scanning and source review.

What is topical nicotinamide used for?

The selected product is licensed for mild to moderate inflammatory acne vulgaris.

Freederm Treatment 4% w/w Gel — Current selected SmPC

Is nicotinamide the same as niacinamide?

Yes. Niacinamide is another name for nicotinamide, the amide form of vitamin B3.

Freederm Treatment 4% w/w Gel — Current selected SmPC

Is nicotinamide an antibiotic?

No. It is a vitamin B3 derivative whose benefit in acne is linked to anti-inflammatory activity rather than antibiotic action.

Freederm Treatment 4% w/w Gel — Current selected SmPC PubMed

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Sources

These sources were used to prepare and review this medicine page.

Freederm Treatment 4% w/w Gel — Current selected SmPCSummary of Product Characteristics · emc

NHSNHS medicine guidance · NHS

PubMedReputable Web · PubMed

NHSNHS medicine guidance · NHS

Prepared and reviewed by the iatroX editorial team.

Explore this medicine

Overview Clinical detail At a glance Uses How nicotinamide works Available preparations Side effects Pregnancy Breastfeeding

Which types of acne does nicotinamide treat?

Its licensed role is mild to moderate inflammatory acne, particularly acne involving inflamed papules and pustules.

Freederm Treatment 4% w/w Gel — Current selected SmPC NHS

Does nicotinamide treat blackheads?

The selected product is licensed for inflammatory acne rather than specifically for blackheads or whiteheads alone.

Freederm Treatment 4% w/w Gel — Current selected SmPC

Does nicotinamide cause niacin flushing?

Characteristic flushing associated with nicotinic acid has not been observed with nicotinamide in the product information.

Freederm Treatment 4% w/w Gel — Current selected SmPC

Can topical nicotinamide be used during pregnancy?

The product information identifies no specific restriction but advises caution, especially during the first trimester; seek professional advice.

Freederm Treatment 4% w/w Gel — Current selected SmPC

Can topical nicotinamide be used while breastfeeding?

The leaflet gives no specific restriction, but professional advice is appropriate, particularly if treatment would be near the breast.

Freederm Treatment 4% w/w Gel — Current selected SmPC

Does topical nicotinamide interact with other medicines?

No medicine interactions are known for the selected topical product.

Freederm Treatment 4% w/w Gel — Current selected SmPC

When should acne treated with nicotinamide be medically assessed?

Seek assessment for painful nodules or cysts, extensive acne, scarring, worsening symptoms or acne that remains troublesome despite treatment.

Use in context. Check current authorised UK product information, local policy and patient-specific factors before prescribing or changing treatment.