medroxyprogesterone acetate + oestrogens, conjugated at a glance
Medicine class
Continuous combined oestrogen–progestogen hormone replacement therapy.
Licensed use
Relief of oestrogen-deficiency symptoms after menopause in people with an intact uterus.
Form
Oral modified-release tablet.
Contraception
It does not prevent pregnancy.
What is medroxyprogesterone acetate + oestrogens, conjugated used for?
The selected product is licensed for:
Hormone replacement therapy for oestrogen-deficiency symptoms after menopause in people with an intact uterus.
How does medroxyprogesterone acetate + oestrogens, conjugated work?
Conjugated oestrogens replace some oestrogen lost after menopause. Medroxyprogesterone acetate opposes oestrogen’s effect on the womb lining, reducing but not completely removing the risk of endometrial overgrowth.
How to take medroxyprogesterone acetate + oestrogens, conjugated
Follow the prescriber’s instructions and the arrows on the blister pack.
Swallow the modified-release tablet whole.
Do not divide, crush or remove the coating, as this may alter drug release.
It may be taken with or without food.
medroxyprogesterone acetate + oestrogens, conjugated side effects
Common or expected effects
- Breast pain or tenderness
- Breakthrough bleeding or spotting
- Vaginal inflammation or discharge
- Low mood
- Joint pain or leg cramps
- Weight change
- Raised triglycerides
Get urgent medical advice
- Symptoms of a blood clot, heart attack or stroke
- Severe allergic reaction
- Yellow skin or eyes
- New migraine-type headache or marked blood-pressure rise
- New breast lump or other breast change
- Heavy, persistent or newly developing vaginal bleeding
- Severe abdominal pain that may indicate pancreatitis or gallbladder disease
medroxyprogesterone acetate + oestrogens, conjugated in pregnancy
This treatment is intended for postmenopausal use and is not contraception. If pregnancy occurs or is suspected, stop taking it and contact the prescriber.
medroxyprogesterone acetate + oestrogens, conjugated while breastfeeding
The selected product is not indicated during breastfeeding. Combined HRT is not usually prescribed while breastfeeding unless a specialist recommends it.
medroxyprogesterone acetate + oestrogens, conjugated interactions
Ask a prescriber or pharmacist to check other medicines and herbal products before treatment or when they change.
Phenobarbital, phenytoin or carbamazepine
May reduce HRT exposure and alter bleeding patterns.
Rifampicin or rifabutin
May increase hormone metabolism, reducing effect and changing bleeding patterns.
Nevirapine, efavirenz, ritonavir or nelfinavir
May reduce hormone exposure and alter bleeding patterns.
Common questions about medroxyprogesterone acetate + oestrogens, conjugated
Answers are fully visible for fast scanning and source review.
What is it used for?
It is licensed to relieve oestrogen-deficiency symptoms after menopause in people who still have a womb.
Why does it contain a progestogen?
Medroxyprogesterone acetate opposes oestrogen’s effect on the womb lining and reduces the risk of endometrial overgrowth.
Can the tablets be crushed?
No. Swallow them whole; crushing, dividing or removing the coating may affect modified release.
Can it prevent pregnancy?
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.