macrogol 3350 + potassium chloride + sodium chloride + sodium hydrogen carbonate + sodium sulfate, anhydrous at a glance
Medicine class
Osmotic bowel-cleansing preparation with electrolytes.
Usual role
Cleans the colon before colonoscopy, barium enema or surgery requiring an empty colon.
Form
Powder dissolved in water to make a clear oral solution.
Hydration
The prepared solution does not replace normal fluid intake; maintain hydration as instructed by the clinical team.
What is macrogol 3350 + potassium chloride + sodium chloride + sodium hydrogen carbonate + sodium sulfate, anhydrous used for?
The selected product is licensed for colonic lavage before procedures requiring a clean colon.
Colonoscopy or another diagnostic examination requiring an empty colon.
Barium enema.
Colonic surgery or another surgical procedure requiring bowel cleansing.
How does macrogol 3350 + potassium chloride + sodium chloride + sodium hydrogen carbonate + sodium sulfate, anhydrous work?
Macrogol 3350 holds water within the bowel by osmosis. This increases intestinal contents and stimulates colonic movement, producing extensive watery evacuation. The included electrolytes are intended to reduce net changes in water and electrolyte balance, although clinically important disturbances can still occur in susceptible people.
How to take macrogol 3350 + potassium chloride + sodium chloride + sodium hydrogen carbonate + sodium sulfate, anhydrous
Prepare and take it exactly according to the hospital's procedure instructions. Dissolve the powder fully in the specified amount of water and stir until clear; do not swallow the dry powder. Stay near a toilet, maintain permitted clear-fluid intake and follow the clinical team's food restrictions. Slow or temporarily stop administration and contact the team if significant nausea, vomiting, abdominal swelling or pain develops.
Do not regard the prepared solution as a replacement for normal permitted fluids.
The prepared solution may be refrigerated and must be discarded if not used within 24 hours.
Tell the team if you have swallowing difficulty, reflux, reduced alertness or a tendency to regurgitate or aspirate.
macrogol 3350 + potassium chloride + sodium chloride + sodium hydrogen carbonate + sodium sulfate, anhydrous side effects
Common or expected effects
- Nausea or vomiting
- Abdominal pain, swelling or wind
- Anal discomfort
- Thirst
- Headache or dizziness
Get urgent medical advice
- Dehydration or electrolyte disturbance, which may cause confusion, seizures or marked weakness
- Irregular heartbeat or palpitations
- Severe allergic reaction, including facial swelling or breathing difficulty
- Persistent forceful vomiting with chest, neck or abdominal pain, which may indicate oesophageal injury
- Sudden abdominal pain with rectal bleeding, which may indicate ischaemic colitis
- Aspiration into the lungs, particularly in people with swallowing or consciousness problems
macrogol 3350 + potassium chloride + sodium chloride + sodium hydrogen carbonate + sodium sulfate, anhydrous in pregnancy
The product-specific SmPC reports no experience in pregnancy and advises use only when the physician considers bowel preparation essential. Although ordinary macrogol laxatives are minimally absorbed and have no known pregnancy risk, that evidence does not remove the need for a procedure-specific assessment of this high-volume preparation.
macrogol 3350 + potassium chloride + sodium chloride + sodium hydrogen carbonate + sodium sulfate, anhydrous while breastfeeding
The product-specific SmPC advises use only when considered essential by the physician. Macrogol 3350 itself has negligible absorption, so transfer into milk and absorption by a healthy, full-term infant are expected to be minimal; maintaining maternal hydration remains important.
macrogol 3350 + potassium chloride + sodium chloride + sodium hydrogen carbonate + sodium sulfate, anhydrous interactions
Rapid bowel emptying can reduce absorption of other oral treatments, and the macrogol component can affect some swallowing thickeners.
Oral medicines generally
Medicines taken around bowel cleansing may pass through without adequate absorption; follow the procedure team's instructions about separating or temporarily managing them.
Medicines with a narrow therapeutic index or short half-life
Reduced absorption may have greater clinical consequences, so medication planning may be required before the procedure.
Oral contraceptive pills
Rapid intestinal transit may reduce absorption; ask the procedure team or pharmacist about contraceptive precautions.
Common questions about macrogol 3350 + potassium chloride + sodium chloride + sodium hydrogen carbonate + sodium sulfate, anhydrous
Answers are fully visible for fast scanning and source review.
What is macrogol 3350 with electrolytes used for before a colonoscopy?
It empties and cleans the colon so the bowel lining can be examined properly.
Is Klean-Prep used for ordinary constipation?
The selected product is licensed for procedural bowel cleansing, not routine constipation treatment.
Can I eat while taking Klean-Prep?
Follow the hospital's dietary instructions. The SmPC requires a period without solid food before administration, but your procedure team may impose additional restrictions.
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.