iomeprol: prescribing and clinical use
Focused clinical detail for use alongside current product information, local policy and patient-specific assessment.
iomeprol: clinical details
Prescribing considerations
- Confirm that contrast-enhanced CT or CT angiography is clinically justified.
- Assess previous contrast reactions, allergy, asthma, renal function, diabetes, hydration, cardiac disease, thyroid disease and relevant neurological disorders.
- Ensure resuscitation facilities are immediately available and observe after administration.
- Use careful injection technique and respond promptly to suspected extravasation.
Contraindications and cautions
- Hypersensitivity to iomeprol or any excipient.
- Do not re-administer after a serious iomeprol-associated cutaneous reaction such as SJS, TEN, AGEP or DRESS.
Monitoring
- Assess renal function in patients at risk and before repeat contrast exposure.
- Monitor for immediate hypersensitivity, cardiovascular or respiratory reactions and inspect the injection site.
- Evaluate thyroid function after exposure in children younger than 3 years and in newborns exposed in utero.
- Consider contrast-induced encephalopathy if acute neurological dysfunction develops.
Clinical pharmacology
Iomeprol is a low-osmolality, non-ionic iodinated contrast agent. It distributes mainly in extracellular fluid, has negligible protein binding, is not metabolised and is eliminated predominantly through the kidneys.
Formulation and product differences
- The selected product is a clear, colourless to pale-yellow solution in a glass multi-dose container.
- It is intended for use with an approved multipatient automatic injector; the stopper should be pierced once and patient connectors replaced after each patient.
- It should not be mixed with other medicines.
iomeprol interactions
Give the imaging team a complete medicine list. Important considerations include:
Metformin
Kidney impairment after intravascular contrast could cause accumulation and lactic acidosis; the clinical team should manage renal function and any temporary interruption.
Beta-blockers
May increase concern about bronchospasm and make a severe contrast reaction harder to treat.
Diuretics and ACE inhibitors
May be associated with a higher risk of adverse reactions, particularly with cardiovascular or renal disease.
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.