galcanezumab at a glance
Medicine class
CGRP-binding humanised monoclonal antibody
Licensed role
Prevention of frequent migraine in adults
How it is given
Injection under the skin using a single-use pre-filled pen
Storage
Keep refrigerated, protected from light and never frozen; limited unrefrigerated storage is permitted under the leaflet’s stated conditions
What is galcanezumab used for?
The selected product is licensed for:
Preventing migraine in adults who have at least four migraine days per month.
How does galcanezumab work?
CGRP is a signalling peptide involved in migraine pain pathways. Galcanezumab binds CGRP and prevents its usual biological effects, reducing susceptibility to migraine attacks.
galcanezumab preparations and strengths
Injection
Route: Parenteral
Strengths: 120 mg
How to take galcanezumab
Galcanezumab is injected under the skin. A healthcare professional should provide training before self-injection.
Suitable areas include the abdomen, thigh, back of the upper arm or buttock.
Rotate injection sites and avoid skin that is tender, bruised, red, hardened or damaged.
Do not use a damaged pen or cloudy, discoloured or particle-containing solution.
Do not shake the pen. Dispose of each used pen in an approved sharps container.
galcanezumab side effects
Common or expected effects
- Pain, redness, itching, bruising or swelling at the injection site
- Constipation
- Vertigo
- Itching or rash
Get urgent medical advice
- Anaphylaxis
- Angioedema, including swelling of the face, lips, tongue or throat
- Serious urticaria or widespread hives, particularly with breathing, swallowing or circulatory symptoms
galcanezumab in pregnancy
Human pregnancy data are limited, and IgG antibodies can cross the placenta. Product information advises avoiding galcanezumab during pregnancy as a precaution. Pregnancy or pregnancy planning should prompt specialist review.
galcanezumab while breastfeeding
It is unknown whether galcanezumab enters human milk. IgG transfer into milk is greatest during the first days after birth and then falls; later use may be considered only when clinically needed following specialist assessment.
galcanezumab interactions
Formal interaction studies have not been conducted, but pharmacokinetic interactions are not expected. The prescriber should still review all medicines and supplements.
Other monoclonal antibodies
No specific interaction is established, but combination experience may be limited, so relevant specialists should review suitability.
Common questions about galcanezumab
Answers are fully visible for fast scanning and source review.
Does galcanezumab prevent migraine or treat an attack already in progress?
It is a preventive treatment and is not intended to relieve an attack after it has begun.
Can galcanezumab be self-injected?
Yes, if a healthcare professional considers this suitable and has provided training.
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.