diphenhydramine hydrochloride + paracetamol + pseudoephedrine hydrochloride at a glance
Licensed use
Relief of symptoms associated with colds and influenza.
Day and night tablets
White tablets are for daytime use; blue tablets are for night-time use only.
Driving
The night-time tablet may cause drowsiness. Do not drive or operate machinery if affected.
Duplicate ingredients
Do not combine with other paracetamol products or medicines containing diphenhydramine.
What is diphenhydramine hydrochloride + paracetamol + pseudoephedrine hydrochloride used for?
This product provides symptom relief rather than treating the underlying infection.
Relief of pain, fever, nasal congestion and related symptoms associated with colds and influenza.
How does diphenhydramine hydrochloride + paracetamol + pseudoephedrine hydrochloride work?
Paracetamol reduces pain and fever. Pseudoephedrine narrows swollen nasal blood vessels to ease congestion. Diphenhydramine blocks histamine H1 receptors and has secretion-drying and sedating effects.
How to take diphenhydramine hydrochloride + paracetamol + pseudoephedrine hydrochloride
Swallow with water and follow the pack leaflet. Use the correctly coloured tablet for the stated time of day; do not take a night-time tablet during the day. Do not take more than directed or combine it with another cough, cold or pain product without checking its ingredients.
Avoid alcohol because it can increase drowsiness.
Do not use the product to sedate a child.
Seek advice if symptoms persist or worsen.
diphenhydramine hydrochloride + paracetamol + pseudoephedrine hydrochloride side effects
Common or expected effects
- Headache
- Drowsiness or sedation
- Difficulty sleeping or nervousness
- Dizziness or impaired concentration
- Blurred vision
- Dry mouth or nausea
- Difficulty passing urine, particularly with prostate enlargement
Get urgent medical advice
- Sudden severe headache, confusion, seizure or visual disturbance
- Swelling of the face, mouth or throat, breathing difficulty or a severe allergic reaction
- Chest pain, stroke symptoms, or a fast or irregular heartbeat
- Sudden loss or reduction of vision
- Sudden abdominal pain or rectal bleeding
- Fever with widespread redness and numerous small pustules
- Severe blistering or peeling skin reaction
diphenhydramine hydrochloride + paracetamol + pseudoephedrine hydrochloride in pregnancy
This combination is generally not recommended during pregnancy unless a doctor considers it necessary. Pseudoephedrine is not recommended because it may reduce placental blood flow, and diphenhydramine should only be used when considered essential. Ask a doctor, midwife or pharmacist about a suitable single-ingredient option.
diphenhydramine hydrochloride + paracetamol + pseudoephedrine hydrochloride while breastfeeding
This combination should usually be avoided while breastfeeding. Pseudoephedrine may reduce milk production, and diphenhydramine may make the infant sleepy. Seek professional advice, particularly if the baby is newborn, premature or unwell, or breastfeeding is not yet established.
diphenhydramine hydrochloride + paracetamol + pseudoephedrine hydrochloride interactions
Check all prescription, pharmacy and shop-bought products for interacting or duplicated ingredients.
Monoamine oxidase inhibitors and reversible MAO inhibitors
Concurrent use, or use soon after stopping them, can cause hypertensive crisis or serotonin toxicity and is contraindicated.
Other decongestants, stimulants and appetite suppressants
Additive effects can increase blood pressure and cardiovascular adverse effects.
Beta-blockers and some other antihypertensives
Pseudoephedrine can oppose blood-pressure control; beta-blocker use is contraindicated for this product.
Common questions about diphenhydramine hydrochloride + paracetamol + pseudoephedrine hydrochloride
Answers are fully visible for fast scanning and source review.
Why are there different day and night tablets?
The daytime tablet contains pseudoephedrine, while the night-time tablet contains sedating diphenhydramine. Both contain paracetamol.
Can it make me sleepy?
Yes. The night-time tablet may cause drowsiness, dizziness and impaired concentration.
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.