calcium chloride dihydrate + histidine + histidine hydrochloride monohydrate + 6 other active ingredients at a glance
Medicine class
Cardioplegic and organ-preservation perfusion solution
Main uses
Cardiac surgery, bloodless-field organ protection and cold preservation of donor organs
Important limitation
Not intended for systemic infusion, fluid replacement or nutritional replacement
What is calcium chloride dihydrate + histidine + histidine hydrochloride monohydrate + 6 other active ingredients used for?
Specialist intraoperative uses include:
Inducing reversible cardiac arrest and protecting the heart during cardiac surgery
Protecting the heart, kidney or liver during surgery in a bloodless field
Perfusing and cold-storing donor hearts, kidneys, livers and pancreases
How does calcium chloride dihydrate + histidine + histidine hydrochloride monohydrate + 6 other active ingredients work?
Its low sodium and calcium composition stabilises cell membranes and limits activating sodium and calcium entry into cells. This reduces organ activity and energy demand during interrupted blood flow, while histidine supports buffering.
How to take calcium chloride dihydrate + histidine + histidine hydrochloride monohydrate + 6 other active ingredients
This solution is not self-administered. A specialist surgical or transplant team perfuses the heart or organ using a technique selected for the procedure.
Use only clear, colourless to pale-yellow solution from an intact container.
Do not administer as an ordinary systemic infusion.
Use immediately after opening and discard any remainder.
Do not mix with other medicines because compatibility has not been established.
calcium chloride dihydrate + histidine + histidine hydrochloride monohydrate + 6 other active ingredients side effects
Get urgent medical advice
- A reduction in blood pressure may occur; its frequency is unknown.
- Systemic uptake of a large amount can cause fluid overload, low calcium or sodium, or high magnesium or potassium.
calcium chloride dihydrate + histidine + histidine hydrochloride monohydrate + 6 other active ingredients in pregnancy
Use requires careful specialist assessment of benefits and risks. For emergency cardiac surgery, aspiration of the solution from the right side of the heart after surgery is advised as a safety precaution.
calcium chloride dihydrate + histidine + histidine hydrochloride monohydrate + 6 other active ingredients while breastfeeding
Use requires an individual specialist benefit–risk assessment because specific safety information is limited.
calcium chloride dihydrate + histidine + histidine hydrochloride monohydrate + 6 other active ingredients interactions
No interactions are known with several medicines commonly used around surgery. The clinical team should still review all current medicines.
Cardiac glycosides, diuretics and nitrates
No interaction is known, but concurrent perioperative treatment remains subject to clinical monitoring.
Antihypertensives, beta-blockers and calcium-channel blockers
No interaction is known, although blood pressure is monitored because the solution may lower it.
Other medicines mixed with the solution
Do not mix because compatibility studies have not been performed.
Common questions about calcium chloride dihydrate + histidine + histidine hydrochloride monohydrate + 6 other active ingredients
Answers are fully visible for fast scanning and source review.
Is this given as a normal intravenous drip?
No. It is not for systemic administration and is used by specialist teams during surgery or organ preservation.
How does it protect organs?
It stabilises cell membranes and reduces cellular activity and energy demand while blood flow is interrupted.
Sources
These sources were used to prepare and review this medicine page.
Prepared and reviewed by the iatroX editorial team.