aminoacridine hydrochloride + lidocaine hydrochloride: clinical use

Prescribing considerations

• Confirm that pain is due to a common mouth ulcer or mechanical denture irritation rather than infection, trauma requiring dental treatment or another oral disorder.
• Review symptoms that persist after product use; long-lasting, atypical, bleeding or increasingly painful ulcers need medical or dental assessment.
• The product is not suitable for teething.

Contraindications and cautions

• Hypersensitivity to lidocaine, aminoacridine or any excipient
• Rare hereditary fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency because the gel contains sucrose

Monitoring

• No routine laboratory monitoring is specified.
• Monitor clinically for hypersensitivity and failure of the lesion to resolve.

Clinical pharmacology

Lidocaine produces reversible local anaesthesia by blocking nerve conduction and is absorbed through oral mucosa before hepatic first-pass metabolism. Aminoacridine is a slow-acting local disinfectant with activity against bacteria and fungi.

Formulation and product differences

• The selected product is an oral gel supplied in an aluminium tube.
• Excipients include sucrose, alcohol, peppermint oil, saccharin sodium and glycerol; consider allergy, intolerance and oral-health implications where relevant.
• Store below 25°C.