Paracetamol Overdose

Assessment and management (N-acetylcysteine treatment).

Reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner)
Last reviewed: 21 October 2025
Emergency MedicineToxicologyHepatology

Clinical Guidelines

BNF: Poisoning, emergency treatment
National
CKS: Poisoning or overdose
National
EASL Clinical Practical Guidelines on the management of acute (fulminant) liver failure
Local
EASL Clinical Practice Guidelines: Drug-induced liver injury
Local
Guidelines for the management of paracetamol poisoning in Australia and New Zealand
Local
Intravenous N-acetylcysteine (NAC) for paracetamol overdose: reminder of authorised dose regimen, possible need for continued treatment with NAC
Local
Management of Acetaminophen Poisoning in the US and Canada: A Consensus Statement
Local
Out-of-hospital assessment and triage of paracetamol poisoning: A consensus statement
Local
Paracetamol Overdose Guidance - RCEM
Local
Treating paracetamol overdose with intravenous acetylcysteine: new guidance
Local
Updated guidelines for the management of paracetamol poisoning in Australia and New Zealand
Local