Paracetamol Overdose

Assessment and management (N-acetylcysteine treatment).

Reviewed by Dr Kola Tytler MBBS CertHE MBA MSt MRCGP (General Practitioner)

Last reviewed: 21 October 2025

Emergency MedicineToxicologyHepatology

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Clinical Guidelines

BNF: Poisoning, emergency treatment

CKS: Poisoning or overdose

EASL Clinical Practical Guidelines on the management of acute (fulminant) liver failure

EASL Clinical Practice Guidelines: Drug-induced liver injury

Guidelines for the management of paracetamol poisoning in Australia and New Zealand

Intravenous N-acetylcysteine (NAC) for paracetamol overdose: reminder of authorised dose regimen, possible need for continued treatment with NAC

Management of Acetaminophen Poisoning in the US and Canada: A Consensus Statement

Out-of-hospital assessment and triage of paracetamol poisoning: A consensus statement

Paracetamol Overdose Guidance - RCEM

Treating paracetamol overdose with intravenous acetylcysteine: new guidance

Updated guidelines for the management of paracetamol poisoning in Australia and New Zealand