Lynch Syndrome (HNPCC)

Overview and management of inherited cancer syndrome.

Reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner)
Last reviewed: 21 October 2025
GeneticsOncologyGastroenterology

Clinical Guidelines

NHS England: Implementing Lynch syndrome testing and surveillance pathways
National
NICE Quality Standard [QS20]: Testing for Lynch syndrome
National
European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender
Local
Genetics of Colorectal Cancer (PDQ®) – Health Professional Version
Local
Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG), Association of Coloproctology of Great Britain and Ireland (ACPGBI) and United Kingdom Cancer Genetics Group (UKCGG)
Local
Guidelines on Genetic Evaluation and Management of Lynch Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer
Local
Hereditary gastrointestinal cancers: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Local
Practice Bulletin No. 147: Lynch Syndrome
Local
Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts (Mallorca Group)
Local