What are the recommended surveillance protocols for patients diagnosed with Lynch Syndrome?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 22 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Recommended surveillance protocols for patients diagnosed with Lynch syndrome include:

  • Consideration of daily aspirin for more than 2 years to reduce the risk of colorectal cancer, noting this is an off-label use as of January 2020.
  • Regular colonoscopic surveillance is implied as part of colorectal cancer prevention strategies, although specific intervals for Lynch syndrome are not detailed in the provided excerpts.
  • Patients should be involved in informed discussions about their care, including the benefits and risks of surveillance and preventive measures.

While the provided NICE guidelines emphasize aspirin use and patient information, detailed colonoscopic surveillance intervals specific to Lynch syndrome are not explicitly stated in the excerpts given.

For comprehensive surveillance protocols, including colonoscopy frequency and other cancer surveillance (e.g., endometrial, ovarian), referral to full NICE guidelines or specialist genetics services is recommended.

References:

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