Klinefelter Syndrome (XXY)

Overview and management of chromosomal disorder.

Reviewed by Dr Kola Tytler MBBS CertHE MBA MSt MRCGP (General Practitioner)

Last reviewed: 21 October 2025

GeneticsEndocrinologyPaediatrics

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Clinical Guidelines

ACOG Practice Bulletin No. 226: Screening for Fetal Chromosomal Abnormalities

Clinical Practice Guideline: Klinefelter Syndrome (XXY) – The Endocrine Society (2010)

Consensus statement on diagnosis and clinical management of Klinefelter syndrome

Consensus statement on diagnosis and clinical management of Klinefelter syndrome