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Knowledge Centre / Anaemia (B12 and Folate Deficiency)

Anaemia (B12 and Folate Deficiency)

Investigation and treatment of macrocytic anaemias.

Reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner)
Last reviewed: 21 October 2025
HaematologyGeneral Practice

Clinical Guidelines

NICE Clinical Knowledge Summary: Anaemia - B12 and folate deficiency
National
NICE guideline [NG239]: Vitamin B12 deficiency in over 16s: diagnosis and management
National
NICE Clinical Knowledge Summary: Anaemia - B12 and folate deficiency
Local
NICE guideline [NG239]: Vitamin B12 deficiency in over 16s: diagnosis and management
Local

Recent iatroX Q&As

  • What initial investigations should I perform for a patient presenting with macrocytic anaemia to differentiate between B12 and folate deficiency?Updated: 8/16/2025
  • How should I interpret the results of serum B12 and folate levels in the context of macrocytic anaemia?Updated: 8/16/2025
  • What are the recommended treatment protocols for B12 deficiency anaemia in adults, including dosing and duration?Updated: 8/16/2025
  • When should I consider referring a patient with macrocytic anaemia for specialist evaluation?Updated: 8/16/2025
  • What follow-up is necessary after initiating treatment for B12 or folate deficiency anaemia to ensure resolution of the condition?Updated: 8/16/2025
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