Amyotrophic Lateral Sclerosis (ALS)

Diagnosis and management of ALS (Motor Neurone Disease).

Reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP (General Practitioner)

Last reviewed: 21 October 2025

Neurology

Clinical Guidelines

European Academy of Neurology (EAN) guideline on the management of amyotrophic lateral sclerosis (ALS)

NICE guideline [NG42]: Motor neurone disease: assessment and management

Canadian best practice recommendations for the management of amyotrophic lateral sclerosis

Canadian best practice recommendations for the management of amyotrophic lateral sclerosis

CANADIAN BEST PRACTICE RECOMMENDATIONS FOR THE MANAGEMENT OF AMYOTROPHIC LATERAL SCLEROSIS

ESPEN guideline clinical nutrition in neurology

European Academy of Neurology (EAN) guideline on the diagnosis and clinical management of amyotrophic lateral sclerosis

Evidence-based consensus guidelines for ALS genetic testing and counseling

Evidence‐based consensus guidelines for ALS genetic testing and counseling

Guideline on clinical investigation of medicinal products for the treatment of amyotrophic lateral sclerosis (ALS)

Home mechanical ventilation for patients with Amyotrophic Lateral Sclerosis: Canadian Thoracic Society Clinical Practice Guideline

Practice Parameter update: The care of the patient with amyotrophic lateral sclerosis (ALS): Multidisciplinary care, symptom management, and cognitive/behavioral impairment (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology

Practice Parameter update: The care of the patient with amyotrophic lateral sclerosis: Drug, nutritional, and respiratory therapies (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology

The clinical practice guideline for the management of amyotrophic lateral sclerosis

Update: The Care of the Patient with Amyotrophic Lateral Sclerosis: Practice Guideline Summary