selumetinib · Medicine question

Is selumetinib recommended during pregnancy?

iatroX medicinesPublished 8 November 2026

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Answer

Koselugo (selumetinib) is not recommended during pregnancy; there are no data in pregnant women, and animal studies have shown reproductive toxicity, including embryo-foetal death, structural defects and reduced foetal weights.

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Koselugo 5 mg granules in capsule for openingAstraZeneca UK Limited · emc · SmPC §4.6 Fertility, pregnancy and lactation · Version 1Document updated 7 July 2026

Sources checked 8 November 2026

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