Answer
Yes, concomitant use of fampridine and cimetidine is contraindicated because cimetidine inhibits OCT2, the transporter responsible for active renal secretion of fampridine.
Sources for this answer
- Fampyra 10 mg prolonged-release tabletsMerz Pharma UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 16Document updated
Sources checked