pyrazinamide · Medicine question

How is pyrazinamide converted into its active antimycobacterial form?

Name: How is pyrazinamide converted into its active antimycobacterial form?
Published: 2026-11-08T02:00:48.264Z

iatroX medicinesPublished 8 November 2026

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Pyrazinamide is converted intracellularly by nicotinic acid amidase, also called pyrazinamidase, into pyrazinoic acid, which has an antimycobacterial effect.

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Pyrazinamide 500 mg tabletsMorningside Healthcare Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 1Document updated 19 June 2025

Sources checked 8 November 2026

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