How is nevirapine metabolised and eliminated from the body?

Nevirapine undergoes extensive hepatic cytochrome P450 oxidation, primarily via CYP3A, to hydroxylated metabolites followed by glucuronidation, with elimination mainly in urine as glucuronide conjugates and less in faeces; under 3% of the dose is excreted unchanged in urine, and nevirapine induces its own metabolism.