How is naltrexone in Mysimba proposed to affect the inhibitory feedback loop on pro-opiomelanocortin (POMC) neurons?

Although Mysimba’s exact appetite-suppressant effects are not fully understood, its naltrexone component is proposed to block β-endorphin-mediated inhibitory feedback at mu-opioid receptors on POMC neurons, facilitating stronger, longer-lasting POMC activation and amplifying bupropion’s effects on energy balance.