amantadine hydrochloride · Medicine question

How is amantadine hydrochloride thought to work in Parkinson's disease?

Name: How is amantadine hydrochloride thought to work in Parkinson's disease?
Published: 2026-11-08T01:35:29.652Z

iatroX medicinesPublished 8 November 2026

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Amantadine hydrochloride is thought to work in Parkinson's disease through low-affinity antagonism at NMDA glutamate receptors and may also exert some anticholinergic activity.

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Amantadine hydrochloride 100mg capsulesAlliance Pharmaceuticals · emc · SmPC §5.1 Pharmacodynamic properties · Version 3Document updated 28 January 2025

Sources checked 8 November 2026

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