Answer
Vernakalant hydrochloride acts preferentially in the atria, blocking potassium and sodium currents to prolong atrial refractoriness and slow impulse conduction in a rate-dependent manner, effects thought to suppress re-entry during atrial fibrillation.
Sources for this answer
- Brinavess 20 mg/ml concentrate for solution for infusionADVANZ Pharma · emc · SmPC §5.1 Pharmacodynamic properties · Version 8Document updated
Sources checked