Answer
Verapamil, a moderate CYP3A4 inhibitor, increases tamsulosin peak concentration (Cmax) and total exposure (AUC) approximately 2.2-fold and solifenacin Cmax and AUC approximately 1.6-fold when taken with Vesomni (solifenacin + tamsulosin), so the combination requires caution.
Sources for this answer
- Vesomni 6 mg/0.4 mg modified release tabletsAstellas Pharma Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 4Document updated
Sources checked