Answer
Co-administration of valproic acid with Temodal (temozolomide) was associated with a small but statistically significant decrease in temozolomide clearance in a population pharmacokinetic analysis of phase II trials; interaction studies were performed only in adults.
Sources for this answer
- Temodal CapsulesMerck Sharp & Dohme (UK) Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 37Document updated
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