Answer
The THC in Sativex acts as a partial agonist at both CB1 and CB2 receptors, mimicking endocannabinoids, which may modulate neurotransmitter effects, including reducing effects of excitatory neurotransmitters such as glutamate.
Sources for this answer
- Sativex Oromucosal SpraySVX Therapeutics Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 9Document updated
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