Answer
Rifampicin reduces THC Cmax and AUC by 40% and 20%, respectively, and CBD Cmax and AUC by 50% and 60%, respectively, in Sativex; concomitant use should be avoided whenever possible.
Sources for this answer
- Sativex Oromucosal SpraySVX Therapeutics Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 9Document updated
Sources checked