Answer
Lidocaine in lidocaine hydrochloride + phenylephrine hydrochloride produces local anaesthesia by acting at sodium channels to block the transient increase in membrane permeability to sodium ions, slowing depolarisation and impairing nerve impulse generation and conduction.
Sources for this answer
- Lidocaine Hydrochloride 5% w/v and Phenylephrine Hydrochloride 0.5% w/v Topical SolutionMartindale Pharma, an Ethypharm Group Company · emc · SmPC §5.1 Pharmacodynamic properties · Version 2Document updated
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