Answer
In Vyxeos liposomal, cytarabine acts during S phase and is converted intracellularly to cytarabine-5-triphosphate (ara-CTP), which appears primarily to inhibit DNA synthesis; its mechanism is not completely understood, and incorporation into DNA and RNA may also contribute to cytotoxicity.
Sources for this answer
- VyxeosJazz Pharmaceuticals UK Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 15Document updated
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